Titlebook: Organelles in Disease; Stine Helene Falsig Pedersen,Diane L. Barber Book 2023 The Editor(s) (if applicable) and The Author(s), under exclu

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Stress Granules in Cancer,timate link between SGs and tumorigenesis. Several pro-tumorigenic signaling molecules including the RAS oncogene, mTOR, and histone deacetylase 6 (HDAC6) have been shown to upregulate SG formation. Based on these studies, SGs have emerged as structures that can integrate oncogenic signaling and tum

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Targeting Cancer Lysosomes with Good Old Cationic Amphiphilic Drugs,h their cancer-promoting and cancer-supporting functions and destabilize their membranes thereby opening intriguing possibilities for cancer therapy. Here, we review the emerging evidence that supports the supplementation of current cancer therapies with lysosome-targeting cationic amphiphilic drugs

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Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondrcancer cells. However, some recent papers that linked MAMs Ca. crosstalk-related upregulation to tumor onset and progression have aroused the interest of the scientific community..In this review, we will describe how different MAMs-localized proteins modulate the effectiveness of Ca.-dependent apopt