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Titlebook: Organ and Species Specificity in Chemical Carcinogenesis; Robert Langenbach,Stephen Nesnow,Jerry M. Rice Book 1983 Plenum Press, New York

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Skin Tumor Promotion: A Comparative Study of Several Stocks and Strains of Mice,e of a carcinogen (initiation phase) followed by repeated treatment with a noncarcinogenic promoter (promotion phase). This second procedure employing initiation and promotion is referred to as two-stage carcinogenesis.
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Species Differences in Response to Aromatic Amines,monkey, steppe-lemming, and X/Gf mouse, among the mammals, have shown resistance to the carcinogenic effects. Metabolic studies, either . or ., have not always provided satisfactory explanations for these differences (3,4,5).
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Promotion of Urinary Bladder Carcinogenesis, involving dogs also demonstrated the necessity for relatively high doses of the carcinogen and the long periods of time required for the experimental induction of bladder cancer (1,2). Aromatic amines since then have remained of central importance in bladder cancer research in animals and in humans.
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