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Titlebook: Optimized Response-Adaptive Clinical Trials; Sequential Treatment Thomas Ondra Book 2015 Springer Fachmedien Wiesbaden 2015 Allocation Sequ

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发表于 2025-3-21 16:10:41 | 显示全部楼层 |阅读模式
书目名称Optimized Response-Adaptive Clinical Trials
副标题Sequential Treatment
编辑Thomas Ondra
视频video
概述Publication in the field of natural sciences.Includes supplementary material:
丛书名称BestMasters
图书封面Titlebook: Optimized Response-Adaptive Clinical Trials; Sequential Treatment Thomas Ondra Book 2015 Springer Fachmedien Wiesbaden 2015 Allocation Sequ
描述Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.
出版日期Book 2015
关键词Allocation Sequence; Backward Induction; Clinical Trial Designs; Policy Iteration; Value Iteration
版次1
doihttps://doi.org/10.1007/978-3-658-08344-1
isbn_softcover978-3-658-08343-4
isbn_ebook978-3-658-08344-1Series ISSN 2625-3577 Series E-ISSN 2625-3615
issn_series 2625-3577
copyrightSpringer Fachmedien Wiesbaden 2015
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Finite Horizon Markov Decision Problems,lman equations. We will see that the class of Markov deterministic policies —that are easier to handle—contain, under assumptions which are often satisfied in practise, optimal policies. Finally, we describe how optimal policies can be calculated, based on a backward induction algorithm. This chapter is based on [Put94], [Whi93], and [Der70].
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Thomas OndraPublication in the field of natural sciences.Includes supplementary material:
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