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Titlebook: Optimization of Pharmaceutical R&D Programs and Portfolios; Design and Investmen Zoran Antonijevic Book 2015 Springer International Publish

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发表于 2025-3-21 18:02:13 | 显示全部楼层 |阅读模式
书目名称Optimization of Pharmaceutical R&D Programs and Portfolios
副标题Design and Investmen
编辑Zoran Antonijevic
视频video
概述Addresses the impact of study design on maximizing the output at the portfolio level in the pharmaceutical industry.Examines portfolio optimization comprehensively by integrating input from multiple s
图书封面Titlebook: Optimization of Pharmaceutical R&D Programs and Portfolios; Design and Investmen Zoran Antonijevic Book 2015 Springer International Publish
描述.Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design and enrichment. Some development strategies that are discussed are indication sequencing, optimal number of programs and optimal decision criteria..This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientis
出版日期Book 2015
关键词Decision Analysis; Decision Making; Optimization; Pharmaceutical Portfolio; Portfolio Optimization; Quant
版次1
doihttps://doi.org/10.1007/978-3-319-09075-7
isbn_softcover978-3-319-34312-9
isbn_ebook978-3-319-09075-7
copyrightSpringer International Publishing Switzerland 2015
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Clinical Aspects of Pharmaceutical Portfolio Managementicially increase or decrease the estimated probability of registration or commercial success. Complex tools, such as including adaptive design principles, and large data software tools can also be utilized to minimize and mitigate the risk and bias embraced by both the R&D and commercial factors
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Need for Optimal Design of Pharmaceutical Programs and Portfolios in Modern Medical Product Developmhat these decisions are made at the portfolio level, as individual programs are interdependent. The value of a product depends on quality of product itself, and quality of development program. The value of a portfolio depends on the value of individual products and the strategy for portfolio optimization. Key concepts that are addressed here are:
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Zoran AntonijevicAddresses the impact of study design on maximizing the output at the portfolio level in the pharmaceutical industry.Examines portfolio optimization comprehensively by integrating input from multiple s
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978-3-319-34312-9Springer International Publishing Switzerland 2015
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Impact of Phase 2b Strategies on Optimization of Drug Development Programswill have a better chance to demonstrate a desirable risk/benefit profile and thus increase the chance of regulatory success and reimbursement by payors. It will also result in improved patient care and greater benefit to society. Multiple papers have been published within industry’s adaptive design working groups, and these are the key findings.
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