书目名称 | Optimization in Drug Discovery | 副标题 | In Vitro Methods | 编辑 | Gary W. Caldwell,Zhengyin Yan | 视频video | | 概述 | Provides updated variations on assays as well as numerous new protocols for drug discovery optimization.Features readily reproducible methods and protocols that are lab-tested and successful.Includes | 丛书名称 | Methods in Pharmacology and Toxicology | 图书封面 |  | 描述 | .Thoroughly revised and updated, .Optimization in Drug Discovery: In Vitro Methods, Second Edition. presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the .Methods in Pharmacology and Toxicology. series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates..Comprehensive and up-to-date, .Optimization in Drug Discovery: In Vitro Methods, Second Edition. aims to guide researchers down the difficult path to successful drug discovery and development.. | 出版日期 | Book 2014Latest edition | 关键词 | Biopharmaceutics; Drug candidates; In vitro and in situ assays; Pharmacodynamic; Pharmacokinetics; Toxico | 版次 | 2 | doi | https://doi.org/10.1007/978-1-62703-742-6 | isbn_softcover | 978-1-4939-6070-5 | isbn_ebook | 978-1-62703-742-6Series ISSN 1557-2153 Series E-ISSN 1940-6053 | issn_series | 1557-2153 | copyright | Springer Science+Business Media New York 2014 |
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