Titlebook: Opioid Agonists, Antagonists and Mixed Narcotic Analgesics; Theoretical Backgrou Enno Freye Book 1987Latest edition Springer-Verlag Berlin

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Spinal and Peridural Analgesia with Opioids,As the conduction of pain impulses via afferent nerve fibres is relayed in the posterior horn of the spinal cord (Fig. 64), a region which has a dense accumulation of opioid receptors, interruption at this relay station may be possible with opioids.

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https://doi.org/10.1007/978-3-642-71854-0CNS; Opioid; analgesics; anesthesia; pain

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Interaction of Mixed Agonist-Antagonists with Different Receptor Sites Using Nalbuphine as a Model cyclazocine. A prototype for the delta-receptor, the binding site for most endogenous opioids, is leucine enkephalin (leu-enkephalin), a pentapeptide. It has a regulatory role in the nervous system for mediating analgesia, behavioural and endocrine changes. The sigma-receptor ligand is SKF10 047 (N-

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Prospects for Future Development,respiratory depression and dependence liability are still the foremost undesirable side effects. Selective antagonists are able to reserve the drawback of a respiratory function impairment. As their use is bound to cardiovascular stimulating effects and because of their short duration of action afte

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