Titlebook: Oligodendrocytes; Methods and Protocol David A. Lyons,Linde Kegel Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2

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Manipulating Neuronal Activity in the Developing Zebrafish Spinal Cord to Investigate Adaptive Myelate neuronal function, such “adaptive” myelination has been proposed as a form of nervous system plasticity, implicated in learning and cognition. The molecular and cellular mechanisms underlying adaptive myelination and its functional consequences remain to be fully defined, partly because it remai

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A Drug-Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation,in which expression of the bacterial enzyme nitroreductase (NTR) is driven under the myelin basic protein promoter (mbp) and thus is expressed in myelinating glia. When NTR-expressing larvae are treated with the prodrug metronidazole, the reaction between NTR and Mtz results in a toxic metabolite wh

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Conditional Demyelination and Remyelination in a Transgenic ,on, and neurodegeneration. The development of immunotherapies, by reducing the relapse rate, has profoundly impacted short-term prognosis and patients’ quality of life. These anti-inflammatory medications, however, have not proven to be sufficient to prevent long-term disability progression, resulti

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Conditional Mutagenesis in Oligodendrocyte Lineage Cells,udy of late-born glial cells that make myelin. A plethora of conditional mutants and Cre-expressing mouse lines is now available to the research community that allows laboratories to readily engage in in vivo analyses of oligodendrocytes and their precursor cells. This chapter summarizes concepts an

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Recent Advances in Live Imaging of Cells of the Oligodendrocyte Lineage,tor for axons, leading to a fast conduction of the action potential, and provides trophic support for the axon, both aspects highly important for the proper function of the nervous system. In the central nervous system, myelination starts shortly after birth and cells from the oligodendrocyte lineag

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The DTA Mouse Model for Oligodendrocyte Ablation and CNS Demyelination,tter understand the demyelination and remyelination processes in adult-onset demyelinating diseases like multiple sclerosis (MS), we have developed the DTA mouse model system that allows for the widespread ablation of the mature oligodendrocytes, resulting in demyelination throughout the central ner

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Human Glial Chimeric Mice to Define the Role of Glial Pathology in Human Disease,ly into murine hosts, in which they outcompete the host glial pool to ultimately colonize and dominate the recipient brains. When congenitally hypomyelinated mutants are used as hosts, the donor hGPCs generate myelinogenic oligodendrocytes as well as astrocytes, so that the recipient mice develop a

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