| 书目名称 | Obesity and Breast Cancer |
| 副标题 | The Role of Dysregul |
| 编辑 | Kristy A. Brown,Evan R. Simpson |
| 视频video | |
| 概述 | Features cutting-edge aromatase research.Explores the application of novel therapies to inhibit aromatase in the breast.Discusses the connection between obesity and breast cancer in older women?.Inclu |
| 丛书名称 | SpringerBriefs in Cancer Research |
| 图书封面 |  |
| 描述 | Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in th |
| 出版日期 | Book 2014 |
| 关键词 | breast cancer; menopause; metabolism; obesity; oestrogen; metabolic disease |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4899-8002-1 |
| isbn_softcover | 978-1-4899-8001-4 |
| isbn_ebook | 978-1-4899-8002-1Series ISSN 2194-1173 Series E-ISSN 2194-1181 |
| issn_series | 2194-1173 |
| copyright | The Author(s) 2014 |
发表于 2025-3-21 16:29:23
