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Titlebook: OPLL; Ossification of the Atsushi Okawa,Morio Matsumoto,Yoshiharu Kawaguchi Book 2020Latest edition Springer Nature Singapore Pte Ltd. 202

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An Overview of Epidemiology and Geneticsn of the spinal cord by an ectopic ossification of the posterior longitudinal ligament. The prevalence of cervical OPLL is 1.9–6.3% in the Japanese, 0.95–3.6% in other Southeast Asians, and 0.01–1.7% in North American and Europeans. OPLL is ordinarily diagnosed after the age of 50 years. While OPLL
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Overview of Recent Basic Researches on OPLL and OLF of ligamentum flavum (OLF), their etiology still remains unclear. However, recently, several breakthroughs in basic researches especially on genetics, biomarkers, stem cells, etc., have taken place. In this chapter, the updates of basic researches are reviewed by frontrunner researchers and the bri
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Histopathological Features of Ossification of the Posterior Longitudinal Ligamentto elucidate the pathogenesis of OPLL for many years, it remains unclear which cell types in the ligament have chondrogenic capacity. Furthermore, the contribution of direct bone formation without chondrogenesis remains elusive. To characterize the osteochondrogenic potential of the cells around the
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Overview of Possible Roles of OPLL-Associated Genes in OPLL Development and susceptibility loci and candidate genes were identified. Among them, R-spondin 2 (.) has been focused on as a potent candidate. RSPO2 is a member of the R-spondin secreted protein family and enhances canonical Wnt signaling activity. A recent study showed that RSPO2 suppresses the early-stage d
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