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Titlebook: Nucleic Acids in Immunology; Proceedings of a Sym Otto J. Plescia,Werner Braun Conference proceedings 1968 Springer Science+Business Media

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书目名称Nucleic Acids in Immunology
副标题Proceedings of a Sym
编辑Otto J. Plescia,Werner Braun
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图书封面Titlebook: Nucleic Acids in Immunology; Proceedings of a Sym Otto J. Plescia,Werner Braun Conference proceedings 1968 Springer Science+Business Media
描述Two fields have played a leading role in biomedical research in recent years, the biochemistry of nucleic acids and immunology. Yet, with the exception of those aspects which have been concerned with antibody synthesis as an example of protein synthesis, there was until recently a lack of direct association between the two fields. Until quite recently the antigenicity of nucleic acids was still in doubt and indeed represented a controversial subject. Also, the exact role of the various nucleic acids in various stages of antibody synthesis was uncertain. These skepticisms and uncertainties disappeared rapidly in the last few years. New experi­ mental approaches brought the realization that nucleic acids, under appropriate conditions, are indeed immunogenic, and that the resulting antibodies can furnish new tools for the exploration of the mplecular structure of the all-important family of nucleic acid molecules. ‘ At the same time, the recognition of the antigenicity of nucleic acids brought a new level of understanding to certain auto-immune diseases and pro­ vided new material for the exploration of the role of a carrier in immune responses. Side by side with this development was
出版日期Conference proceedings 1968
关键词Antigen; biochemistry; biomedical research; chemistry; diseases; immune response; immunology; protein
版次1
doihttps://doi.org/10.1007/978-3-642-87668-4
isbn_softcover978-3-642-87670-7
isbn_ebook978-3-642-87668-4
copyrightSpringer Science+Business Media New York 1968
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The Reaction of Anti-Deoxyribonucleic Acid Sera with Nucleoside and Nucleotide Conjugates of reacting specifically with nucleic acids. Recently, the production of such antibodies has been described; it is based on the use of nucleic acid-protein complexes as antigens or the use of conjugation of nucleic acid derivatives and macromolecules.
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Immunological Evidence for the Existence of Thymine Dimers in Ultraviolet Irradiated DNAn phage DNA’s are highly specific for the glucosylated cytosine moieties (Murakami .., 1961; Townsend .., 1965) and can be used to determine the extent of phage DNA synthesis in T.-infected . cells even though host cell DNA is present in large excess (Levine .., 1960).
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Methylated Bovine Serum Albumin as a Carrier for Oligo- and Poly-Nucleotides our initial experiments DNA-rich preparations extracted from . by a phenol procedure (Braun ., 1957). These preparations contained appreciable protein and carbohydrate material that could not be dissociated easily from the DNA.
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DNA and Nucleoprotein Determinants for Systemic Lupus Erythematosus Seras in studies of DNA and nucleoprotein structure. The determinants have been explored mainly by: (1) comparisons of direct complement (C′)-fixation reactivity of native and denatured DNA, of nucleoprotein, and of artificial DNA-histone complexes; and (2) inhibition of C′-fixation by fragments of the antigens.
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Specificity in the Reaction between Anti-Pyrimidine Nucleoside Antibodies and DNA-nucleoside antibodies, specifically anti-cytidine and anti-thymidine, with native DNA molecules which had been modified chemically so as to contain exposed or nonhydrogen-bonded bases. These studies would serve as a model for future investigations.
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