Titlebook: Nucleic Acids and Molecular Biology; Fritz Eckstein,David M. J. Lilley Book 1994 Springer-Verlag Berlin Heidelberg 1994 DNA.DNA structure.

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The Convertible Nucleoside Approach: Structural Engineering of Nucleic Acids by Disulfide Cross-Linensional structure. Another class of biologically important macro-molecules, nucleic acids, possess the functionality required for hydrophobic packing and metal chelation, but lack the sulfhydryl groups that are necessary for disculfide cross-linking. Hence, the limited repertoire of atoms in nuclei

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The Hairpin Ribozyme, by RNA has been found to be at the heart of critical steps in gene expression, including RNA splicing, endonucleolytic RNA processing, and possibly ribosomal peptide bond formation (Sheldon et al. 1990; Noller et al. 1992; Symons 1992; Cech 1993; Long and Uhlenbeck 1993). In addition, ribozymes wit

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Supercoiling Induced by Transcription,mental question is the extent to which transcription determines the level of DNA supercoiling in vivo. Transcription can induce supercoiling of the template by virtue of the topological relationship between DNA and elongating RNA polymerase (Liu and Wang 1987). In some models, transcription elongati

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Misgiving

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Adaptability and Specificity in DNA Binding by , Repressor, sites. Our present understanding of the mechanisms of repression and activation (gene regulation) has evolved from extensive studies on these sequence-specific DNA binding proteins and their DNA targets. A central question in these studies concerns how the protein distinguishes its target site(s) f

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The , Sliding Clamp of , DNA Polymerase III Holoenzyme Balances Opposing Functions,ssive replication (Kornberg and Baker 1991; Stukenberg et al. 1991). Its ring shape (Fig. 1) allows it to completely encircle DNA while freely diffusing along the duplex (Stukenberg et al. 1991; Kong et al. 1992). The . “sliding clamp” confers onto pol III holoenzyme a high degree of processivity (5