Titlebook: Nucleic Acid Therapeutics in Cancer; Alan M. Gewirtz Book 2004 Springer Science+Business Media New York 2004 DNA.cancer.tumor.tumor growth

Antagonist

Mechanism of Action of Antisense RNA in Eukaryotic Cellstranscripts that have the potential to form duplex RNA hybrids with their target messages .. Although there are numerous examples in the literature of the successful application of antisense strategy, the many failures and frustrations have been less well documented. Recent work from a number of lab

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Identification of Hybridization Accessible Sequence in Messenger RNAAs are inhibited .. We have hypothesized that the inability to predict mRNA structure in vivo is a significant component of this problem because it is not known which regions of an mRNA molecule are accessible for basepairing or other recognition processes. A number of strategies have been developed

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Nucleic Acids As Gene-Targeting Therapeuticspossibility exists that manipulation of expression of the causative gene, or genes, could have significant therapeutic consequences. Furthermore, because biological processes are virtually always the result of the balance between stimulatory and inhibitory effects, it is difficult to imagine a situa

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Book 2004ogy and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. T

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