Titlebook: Nuclear Receptors; Current Concepts and Chris M. Bunce,Moray J. Campbell Book 2010 Springer Science+Business Media B.V. 2010 ATP.Metazoa.Vi

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Nuclear Receptors an Introductory Overview,h the novice and experienced nuclear receptor biologist. For the novice it will provide a background scaffold for the forthcoming chapters. For the most experienced it will serve as a timely reminder of what fun we have had and how far this vitally important field has come since the first report of

GLOSS

What does Evolution Teach us about Nuclear Receptors?,ir diversity can be helpful to make insights about their evolution. Significant attention is paid to the evolution of ligand-binding ability. Recent evolutionary and functional data have challenged the traditional concept of ligand, providing a more complex view of the mechanisms by which the transc

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preservative

The Glucocorticoid Receptor,ammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders. The effects of glucocorticoids and their synthetic derivatives are mediated by the glucocorticoid receptor (GR, NR3C1), a member of the n

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Androgen Receptor,ihydrotestosterone (5α-DHT). AR function can be regulated by the binding of its ligands, either agonists or antagonists, which initiate sequential conformational changes of the receptor that will affect receptor function. At the cellular level, AR mainly acts as a transcription factor to regulate do

recede

Junction

The Vitamin D Receptor (NR1I1),edes the isolation of the receptor by approximately 300 years. The VDR plays a significant role in regulating serum calcium levels through its actions on the cellular machinery to absorb calcium in the gut, to re-absorb it in the kidneys and deposit it in the bones. Consequently, insufficiency of th

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Retinoic Acid Receptors,s cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells. The effects are mainly mediated by two types of nuclear receptors – retinoic acid receptors and reti

cardiac-arrest

PPARs: Important Regulators in Metabolism and Inflammation,ubtype is characterized by a specific tissue expression pattern, partially accounting for distinct biological functions. Analogous to many other nuclear receptors, PPARs form heterodimers with the retinoid X receptor and regulate DNA transcription by binding to specific response elements present in