Titlebook: Nuclear Medicine and Immunology; Sara Harsini,Abass Alavi,Nima Rezaei Book 2022 Springer Nature Switzerland AG 2022 Radioimmunotherapy.Mol

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Nuclear Imaging of Endogenous Markers of Lymphocyte Response,rmation, emphasizing the need for superior imaging probes that can provide macroscopic and accurate assessments of immune cells and their functional states in real time. Lymphocytes, comprising of T cells, B cells, and natural killer (NK) cells, have been a primary focus in the immune imaging field

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Radioimaging of Activated T Cells in Preclinical and Clinical Cancer Investigations,lls to gain insights into the complex nature of cancer immunotherapy (CIT). The goal of CIT is to achieve specific tumor cell eradication while imposing minimal systemic toxicity. Yet, the high cost of CIT and the challenges associated with patient stratification present clinicians with significant

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Gallium Imaging of Infection and Inflammation,e entities. In instances where a definite distinction between the two processes is required in order to best manage the patient, time may not be sufficient to wait for the results of time-consuming cultures. Imaging provides a noninvasive diagnostic tool, which, when applied as positron emission tom

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[99mTc]Tc-HMPAO-Labeled Leukocyte Imaging of Infection and Inflammation,the suspicion of an infection, but confirming this can be a real diagnostic dilemma. In other cases, the clinical findings may not be localizing, and anatomic imaging modalities might be nondiagnostic. This chapter will review the technical aspects of labeling leukocytes, their biodistribution and r

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Tumor-Targeting Agents,for imaging as well as therapy. The process of protein engineering improves antibody’s pharmacokinetics retaining the property of affinity and specificity. Using a single-chain variable fragment as the building block, imaging with antibody variants provides high-contrast, good-quality images using s

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Tumor Architecture and Targeted Delivery,oplasms. The current therapies’ failure may be due to the complicated procedure in interstitial drug transport. Tumor microenvironment (TME) has been recognized as the driver of the complex and heterogeneous tumor ecosystem. With the advancement in molecular imaging, there is the development of targ