Titlebook: Novel Therapeutics for Rare Lymphomas; Christopher Dittus Book 2020 Springer Nature Switzerland AG 2020 lymphoma.novel therapeutics for ra

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Anaplastic Large Cell Lymphoma,naplastic lymphoma kinase-positive (ALK-positive) ALCL generally having a better prognosis and occurring in younger patients than ALK-negative ALCL. Multiagent chemotherapy, now with the addition of brentuximab vedotin, an anti-CD30 monoclonal antibody-drug conjugate, is the recommended initial ther

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Enteropathy-Associated T-Cell Lymphomas, that primarily present in the intestine and were previously collectively termed EATL. Given their distinct immunohistochemistry, mutational profile, and epidemiology, they were formally separated in 2016. Many patients present with an acute abdomen and are diagnosed during laparotomy. While outcome

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Hepatosplenic T-Cell Lymphoma,ggressive, morbid, or fatal clinical course. Here we review the molecular/biologic basis as well as salient clinical features, diagnostic criteria, and current treatment pathways in this disease. Lastly, we describe potential ways forward for improving the outcome in this dreaded disease based upon

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,Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome,ll review the most common classifications of CTCL, which include mycosis fungoides (MF), MF variants, and Sézary syndrome (SS). Clinical and pathologic staging systems will be discussed in detail along with the implication of staging on clinical outcomes. Current therapy approaches consist of topica

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The Hematopathology and Diagnostic Challenges of Rare Lymphomas,erscore the need for continued clinical and biologic investigation and a careful interdisciplinary approach to patient care. This chapter introduces the complexity and nuance involved in the diagnosis of lymphoma. There will be a particular emphasis on uncommon lymphoma subtypes and diagnostic pitfalls.

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Christopher DittusDiscusses the clinical presentation, diagnosis, and treatment approach to rare lymphomas.Focuses on new diagnostic approaches, novel chemotherapy combinations, and new treatment modalities with novel

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