Titlebook: Novel Approaches to Selective Treatments of Human Solid Tumors; Laboratory and Clini Youcef M. Rustum Book 1993 The Editor(s) (if applicabl

Mundane

Leucovorin as a Prodrugizes the inhibitory ternary complex formed between the FU active metabolite, FdUMP and thymidylate synthase, resulting in suppression of DNA synthesis or repair.. It has been demonstrated both in animal models. and in humans. that administration of leucovorin results in intratumor elevation of CH.FH

树木中

Clinical Use of Leucovorin: Intracellular Metabolismand upper aerodigestive system. While many analogs of 5-fluorouracil have been synthesized since the early 1960’s none has supplanted 5-fluorouracil for general clinical use. One of the major focal points of recent investigative work has been efforts to enhance the activity of 5-fluorouracil through

Heart-Attack

清洗

Effects of 5-Fluorouracil on mRNAcols which are dependent upon 5-fluorouracil (FU). The basis for this interest rests largely upon the exquisite sensitivity of the enzyme to the antimetabolite 5-fluorodeoxyuridylate, the demonstration of numerous cell culture effects which can be explained by enzyme inhibition, and increased tumor

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EVEN

拱形面包

5-Fluorouracil Combined with the Pure [6S]-Stereoisomer of Folinic Acid in High Doses for Treatment luorouracil (5-FU) and fluorodeoxyuridine (FUdR)] . (1,2,3). Potentiation of the antitumor activity of 5-FU by folinic acid has been demonstrated in patients with gastrointestinal carcinomas (4–10); this has resulted in effective palliative treatment for patients with advanced colorectal adenocarcin

间谍活动

5-Fluorouracil Modulation in Colorectal Carcinoma Experience of German Investigators of FU. Among the modulating agents folinic acid (FA) has been proven to increase response rates, while its impact on patients survival is still questionable.. Nevertheless FU in combination with FA is considered by most oncologists as standard treatment in advanced stages of colorectal cancer. Its

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