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Titlebook: Novel Anticancer Drug Protocols; John K. Buolamwini,Alex A. Adjei Book 2003 Springer Science+Business Media New York 2003

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Immunohistochemical Determination of EGFR-Tyrosine Kinase Inhibition in Clinical SampleserbB3 (HER3), and erbB4 (HER4). EGFR (erbB1) was the first member to be described and sequenced (.). The EGFR is a 170 kDa plasma membrane glycoprotein composed of a single polypeptide chain of 1186 amino acids (.,.). The receptor consists of an extracellular ligand-binding domain, a transmembrane l
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Immunohistochemical Assays of Farnesyltransferase Inhibition in Patient Samplestransferase (FT) as a potential target of antineoplastic therapy (.–.). At the present time, three different FT inhibitors (FTIs), SCH66336, R115777, and BMS-214662, are undergoing clinical testing. Phase III studies with R115777 in pancreatic and colorectal cancer have completed accrual. Because th
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Inflammatory Response of Tumor-Activated Hepatic Sinusoidal Endothelium as a Target for the Screeninriers, and cancer-induced immune cell disfunction and neo-angiogenesis. Proinflammatory cytokine blockade inhibits cancer metastasis development under experimental conditions (.,.), suggesting that proinflammatory mediators regulate host-tumor cell interactions contributing to arrest and implantation of disseminated cancer cells in target organs.
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