Titlebook: Notch Signaling in Embryology and Cancer; Notch Signaling in C Jörg Reichrath,Sandra Reichrath Book 2021 The Editor(s) (if applicable) and

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NOTCH and Esophageal Squamous Cell Carcinoma,ies have shown that . mutations are commonly seen in human ESCC. This chapter summarizes our current understanding of the NOTCH pathway in normal esophagus and in ESCC. In normal esophagus, NOTCH pathway regulates the development of esophageal squamous epithelium, in particular, squamous differentia

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Notch in Head and Neck Cancer,h an aggressive, invasive evolution. Due to the heterogeneity of the tissues affected, it is particularly challenging to study the molecular mechanisms at the basis of these tumors, and to date we are still lacking accurate targets for prevention and therapy. The Notch signaling is involved in a var

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,Notch Signaling and Human Papillomavirus–Associated Oral Tumorigenesis,netically engineered mouse models, Notch1 acts as one of the first steps to commit basal keratinocytes to terminally differentiate. Similarly, in human head and neck squamous cell cancers (HNSCCs), NOTCH1 is often lost consistent with its essential tumor-suppressive role for initiating keratinocyte

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The Impact of Notch Signaling for Carcinogenesis and Progression of Nonmelanoma Skin Cancer: Lesson(SCC) are the major types of NMSCs, representing approximately 70% and 25% of these neoplasias, respectively. Because of their continuously rising incidence rates, NMSCs represent a constantly increasing global challenge for healthcare, although they are in most cases nonlethal and curable (e.g., by

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The Relevance of Notch Signaling in Cancer Progression,fferentiation, and cell death by short-range signaling between nearby cells that come in contact. The Notch pathway has also been critically involved in the pathobiology of a variety of malignancies, regulating cancer initiation and development, as well as early stages of cancer progression, by adju

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