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Titlebook: Nonanticoagulant Actions of Glycosaminoglycans; Job Harenberg,Benito Casu Book 1996 Plenum Press, New York 1996 Alzheimer.Oligosaccharid.b

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书目名称Nonanticoagulant Actions of Glycosaminoglycans
编辑Job Harenberg,Benito Casu
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图书封面Titlebook: Nonanticoagulant Actions of Glycosaminoglycans;  Job Harenberg,Benito Casu Book 1996 Plenum Press, New York 1996 Alzheimer.Oligosaccharid.b
描述Prophylaxis and treatment of thromboembolism have made one of the major impacts in medicine. Heparin has widely been used as the most effective drug during the last 50 years. However, its potential side effects have led to the search for equally effective but safer alternatives. At present, the low-molecular-weight heparins are the most promising steps in this direction. Considerable interest has been generated at the same time in exploring other gly­ cosaminoglycans of the nonheparin type for therapeutic use. The existence of these com­ pounds has been known for a long time and substantial information has been gathered on glycosaminoglycans such as heparinsulfate, dermatansulfate, and chondroitinsulfate. Many of these substances are derived from animal or plant sources, and some of them have now been synthesized. The aim of the Fourth Symposium on Glycosaminoglycan Research at Villa Vigoni in Loveno at Lake Comolltaly was to summarize the considerable new information in this field. The articles of the present volume are mainly based on a German-Italian collaboration supported by the Vigoni Program. The selected articles describe many different, nonheparin glycosaminoglycans, some
出版日期Book 1996
关键词Alzheimer; Oligosaccharid; biotechnology; clinical trial; drug; pharmacology; protein; research
版次1
doihttps://doi.org/10.1007/978-1-4613-0371-8
isbn_softcover978-1-4613-8021-4
isbn_ebook978-1-4613-0371-8
copyrightPlenum Press, New York 1996
The information of publication is updating

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发表于 2025-3-21 20:49:44 | 显示全部楼层
Protein Binding of Sulfated Glycosaminoglycans,mal tissues and in cell surfaces as proteoglycans, i.e., as polysaccharide chains covalently attached, comb-like, to serine residues of polypeptide chains. The number and length of GAG chains linked to the polypetide matrices varies for different proteoglycans, and for the same proteoglycan in different cells..
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Book 1996uring the last 50 years. However, its potential side effects have led to the search for equally effective but safer alternatives. At present, the low-molecular-weight heparins are the most promising steps in this direction. Considerable interest has been generated at the same time in exploring other
发表于 2025-3-22 05:14:55 | 显示全部楼层
ive drug during the last 50 years. However, its potential side effects have led to the search for equally effective but safer alternatives. At present, the low-molecular-weight heparins are the most promising steps in this direction. Considerable interest has been generated at the same time in explo
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Application of Mass Spectrometry to the Analysis of Natural and Synthetic Sulfated Oligosaccharidesthe development of refined techniques of carbohydrate synthesis (5) opened up the possibility to produce synthetic sulfated oligosaccharides; some of them presenting relevant pharmacological activities (6).
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Monoclonal Antibody Directed Against Heparin and Heparin-Fractions,sulfate, dermatan sulfate, chondroitin sulfate A and C. Oversulfated heparin showed lower affinity to the antibody H 1.18 than 2–0-and 6–0-desulfated heparin..In conclusion, the present paper describes an IgG 1 monoclonal directed against heparin fractions between 4.500 and 6.500 dalton, which can be used for biological measurements.
发表于 2025-3-23 00:56:53 | 显示全部楼层
Non-Anticoagulant Actions of Glycosaminoglycans,c saccharide sequence,. that is present in approximately one-third of the molecules of commercial UFH,. while the non-specific binding of UFH to the other plasma proteins appears to be related to heparin molecular size, the higher molecular weight chains showing a greater affinity binding than those of lower molecular weight..
发表于 2025-3-23 02:19:40 | 显示全部楼层
New NMR Spectroscopic Approaches for Structural Analysis of Glycosaminoglycans,Nuclear Magnetic Resonance (NMR) spectra provide detailed information on the structure and interactions of molecules, mainly because a molecular system gives signals at different frequency values as a function of the type and molecular environment of magnetically active nuclei.
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