Titlebook: Non-Disseminated Breast Cancer; Controversial Issues Gilbert H. Fletcher (Professor),Seymour H. Levitt Book 1993 Springer-Verlag Berlin He

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Is Breast Cancer Curable?,(using a 5-year survival index) of patients with breast cancer were not affected by treatment at all (P. and L. 1951). Other authors concluded, by constructing mathematical models of the behavior of breast cancer, that the same proportion of patients at any time during follow-up experience failure,

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Criteria of Operability in Advanced Breast Cancer,enth Century, and became the mainstay for treat-ment. The lack of benefit from this Operation for some patients was first appreciated by Haagensen who, in classic publications with S. in 1942 and 1943, described clinical features that were predictors of a shortened life expectancy after radical mast

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Postoperative Radiotherapy and the Pattern of Distant Spread in Breast Cancer,nce of local recurrences has been observed in all studies. This finding demonstrates the eflfect of irradiation on residual neoplastic tissue (T. and S. 1987). However, the impact of this treatment on long-term survival remains controversial and there is a large discrepancy between the highly eflect

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How Much of the Effect of Chemotherapy Is Due to Hormonal Manipulation?,n made. It has now been conclusively shown that a treatment intervention given after surgery for operable or early breast cancer can improve long-term survival as well as perturb the natural history of breast cancer. Administering adjuvant systemic therapy to patients presenting with seemingly local

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Chemotherapy for Node-Negative Breast Cancer,scussion has been greatly strengthened in recent years by the publication of several large overviews of adjuvant systemic breast cancer therapy, the most recent of which analyzes results from randomized studies of 75 000 women (E. B. C. T.’ C. G. 1992). In this chapter we present some of the issues

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Treatment of the Peripheral Lymphatics: Rationale, Indications, and Techniques, regional lymphatics. Regional lymph node irradiation is frequently performed in patients with breast cancer who present with advanced stage disease, but the efficacy of such radiation in patients with limited stage breast cancer continues to remain controversial despite decades of study. Results of

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What Is the Value of Clinical Trials?, emotionally laden issues, there is difficulty letting go of long-held views of treatment that have provided some degree of help and subsequent security for both physicians who administer treatment and for patients who receive it. It is expected, therefore, that controversy develops when new therapi

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What Have We Learned from the Stockholm Trials on Adjuvant Radiation Therapy in Early-Stage Breast -free survival for patients with early-stage breast cancer (F. et al. 1975; B. et al. 1976). Since then there has been a continued emphasis on the use of adjuvant systemic therapy in the primary management of breast cancer. Unfortunately, advocates for this type of treatment have sometimes underrate