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Titlebook: Non-Alcoholic Fatty Liver Disease; A 360-degree Overvie Elisabetta Bugianesi Book 2020 Springer Nature Switzerland AG 2020 Steatohepatitis.

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Book 2020g cause of chronic liver disease in Europe, North and South America and Asia – and to share the latest information on evolving approaches to diagnosis and treatment. The book offers a comprehensive overview of the current topics of interest in the field, and provides clinical guidance on NAFLD throu
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Obesity and NAFLD: Same Problem?,accumulation and insulin resistance mutually feed each other, and progressive lipotoxicity, i.e., accumulation of fat in adipose tissue stores, finally involves several organs, including the liver. The primary defect may be genetic in origin, or promoted by epigenetic modifications, or, more commonl
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The Burden of NAFLD Worldwide,t that 25% of the world have NAFLD. Although only a small proportion of NAFLD patients will progress to end-stage liver disease and death, due to the sheer number of individuals affected worldwide, the clinical burden of NAFLD is substantial. In fact, NAFLD is now one of the leading causes of cirrho
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Histopathology of Nonalcoholic Fatty Liver Disease,esent in all patients and nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD that may be accompanied by fibrosis leading in some patients to advanced liver disease with cirrhosis. Hepatocellular carcinoma may develop in a background of pre-cirrhotic NASH or NASH cirrhosis. Currently,
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NAFLD and Insulin Resistance: A Multisystemic Disease,with type 2 diabetes (T2D) where the prevalence is much higher. The pathophysiology of NAFLD is still not completely understood. However, alteration in both glucose and lipid metabolism, mainly because of impairment in insulin action (i.e., insulin resistance) and insulin secretion, is among the maj
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Etiopathogenesis of NAFLD: Diet, Gut, and NASH,a is deeply implicated in the pathogenesis of liver steatosis and the progression to nonalcoholic steatohepatitis (NASH) and liver fibrosis..Gut microbiota composition and gene expression are independently linked to NAFLD, as well as to many known risk factors for NAFLD such as obesity and insulin r
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The Natural History of NAFLD: Environmental vs. Genetic Risk Factors,fibrosis, the main risk factor for liver-related events and for hepatocellular carcinoma. In particular, about 10–30% of NAFLD patients can develop nonalcoholic steatohepatitis (NASH), which more frequently progresses to advanced liver disease. However, development of cardiovascular complications an
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NAFLD, Diabetes, and Other Endocrine Diseases: Clinical Implications,ocrinologists. NAFLD affects up to 70–80% of patients with type 2 diabetes (T2DM) and up to 30–40% of adult patients with type 1 diabetes. Compelling evidence indicates that the coexistence of NAFLD and diabetes mellitus increases the risk of developing not only the more severe forms of NAFLD but al
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NAFLD and Cardiovascular and Cardiac Disease: Clinical Implications, in the past few decades, there has been a decline in CVD age-adjusted mortality rates in the developed world, the recent increase in prevalence of metabolic diseases such as NAFLD and type 2 diabetes that are both strongly associated with central obesity and metabolic syndrome, is likely to slow, o
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