Titlebook: Nitric Oxide: From Research to Therapeutics; Arunabha Ray,Kavita Gulati Book 2023 The Editor(s) (if applicable) and The Author(s), under e

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Nitric Oxide-cGMP-PKG Signaling in the Cardioprotective Effects of Phosphodiesterase 5 Inhibitors,ase in bioavailability of cGMP which exerts its downstream signaling effects through the activation of protein kinase G (PKG). The dysregulation of cGMP-PKG signaling cascade plays a critical role in the pathology of several cardiovascular disorders. PDE5 inhibitors including sildenafil and tadalafi

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Role of Nitric Oxide Synthase and Nitric Oxide Signaling in the Neutrophil Ontogeny and Functions,ide (NO), a pleiotropic signaling molecule produced from nitric oxide synthases, regulates neutrophils at diverse levels. This includes the development of neutrophils from hematopoietic stem cells through granulopoiesis processes; furthermore, nitric oxide regulates neutrophil maturation from commit

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Cell Death-NO-Today: Effect of NO and RNS on Non-apoptotic Regulated Cell Death,as a signalling molecule in cell, however, deregulated production of NO generates several reactive nitrogen species (RNS). Through diffusion controlled reaction NO and RNS can exert detrimental effects on cellular lipids, proteins and DNA. NO and RNS influence glycolysis, mitochondrial respiration,

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Therapeutic Potential of Nitric Oxide in the Management of COVID-19 Induced Acute Respiratory Distrsease 2019 (COVID-19) pandemic. The SARS-CoV-2 virus has caused massive health as well as the socioeconomic crisis globally. The virus induces an airway infection, affecting gas exchange by primarily targeting alveolarepithelial and endothelialvessels,resulting in acute respiratory distress syndrome

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