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Titlebook: Nitric Oxide (NO) and Cancer; Prognosis, Preventio Benjamin Bonavida Book 2010 Springer Science+Business Media, LLC 2010 apoptosis.cancer.c

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发表于 2025-3-21 19:12:26 | 显示全部楼层 |阅读模式
书目名称Nitric Oxide (NO) and Cancer
副标题Prognosis, Preventio
编辑Benjamin Bonavida
视频video
概述the first volume to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer thera
丛书名称Cancer Drug Discovery and Development
图书封面Titlebook: Nitric Oxide (NO) and Cancer; Prognosis, Preventio Benjamin Bonavida Book 2010 Springer Science+Business Media, LLC 2010 apoptosis.cancer.c
描述.Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies..
出版日期Book 2010
关键词apoptosis; cancer; cancer therapy; cancer treatment; carcinogenesis; carcinoma; cell; immunotherapy; leukemi
版次1
doihttps://doi.org/10.1007/978-1-4419-1432-3
isbn_softcover978-1-4614-2611-0
isbn_ebook978-1-4419-1432-3Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightSpringer Science+Business Media, LLC 2010
The information of publication is updating

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发表于 2025-3-21 22:09:51 | 显示全部楼层
Dual Role of Nitric Oxide in Cancer Biologyarious attempts toward developing NO-based cancer therapy are still in primitive stages, and a clear understanding of the levels of NOS expression, its timing, and the concentrations of NO produced in the tumor microenvironment is key to the development of novel strategies for tumor treatment and pr
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Nitric Oxide and Life or Death of Human Leukemia Cells pro-drugs can induce apoptosis and death of many neoplastic cells in vitro in an immunologically nonspecific manner. NO can also inhibit apoptosis and death of tumor cells by blocking activity of caspases. Malignant cells may express NO synthase (NOS), and NOS inhibitors induce apoptosis of these c
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Inhibition of Apoptosis by Endogenous Nitric Oxide in Chronic Lymphocytic Leukaemiacases protecting cells against spontaneous or induced apoptosis. In CLL cells, the level of endogenous NO is correlated with the abundance of mitochondria and resistance to apoptosis. NO inactivates caspase(s) through oxidation and S-nitrosylation of a cysteine present in their active site, providin
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Nitric Oxide Inhibits Tumor Cell Metastasis via Dysregulation of the NF-κB/Snail/RKIP Loopressor Snail. NO-induced inhibition of NF-κB and Snail and induction of RKIP established the NO-induced dysregulation of the NF-κB/Snail/RKIP circuitry in the regulation of metastasis. These findings suggest the therapeutic role of NO donors in the inhibition of metastasis.
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Role of Nitric Oxide for Modulation of Cancer Therapy ResistanceDNA repair proteins also contributes to sensitivity of tumors to chemo- and radiotherapy. Hypoxic tumors tend to accumulate cells with mutations in the tumor suppressor gene, .. NO activates wild-type p53 protein by peroxynitrite-mediated DNA damage and exerts resistance-modulating effects on wild-t
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