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Titlebook: Nisoldipine 1987; P. G. Hugenholtz,J. Meyer Conference proceedings 1987Latest edition Springer-Verlag Berlin Heidelberg 1987 angina pector

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书目名称Nisoldipine 1987
编辑P. G. Hugenholtz,J. Meyer
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图书封面Titlebook: Nisoldipine 1987;  P. G. Hugenholtz,J. Meyer Conference proceedings 1987Latest edition Springer-Verlag Berlin Heidelberg 1987 angina pector
描述This book, the first to provide a comprehensive overview of all studies so far carried out with this second-generation calcium entry blocker, Nisoldipine, is the fruit of a- day conference. In the first part the essential data on its experimental and clinical pharmacology are summarised by outstanding research workers in this field. The second part contains work concerning the major action of the drug, namely its effect in reducing vasomotor tone. The third part deals with intravenous or oral administration. From these data a clear profile develops, which is effective in angina pectoris of various forms and in cardiac ischaemia, both the clinically evident and the silent forms. Additionally, exploratory data in the area of cardiac failure are presented. As several contributors are based on material presented as a poster they do not contain a reference list. This book is highly recommended for all those investigators and clinicians who are researching for the optimal calcium entry blocker.
出版日期Conference proceedings 1987Latest edition
关键词angina pectoris; calcium; drug; heart; research
版次1
doihttps://doi.org/10.1007/978-3-642-73010-8
isbn_softcover978-3-540-18394-5
isbn_ebook978-3-642-73010-8
copyrightSpringer-Verlag Berlin Heidelberg 1987
The information of publication is updating

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Pharmacokinetics of Nisoldipine.5–5.5 ng/ml. It has linear pharmacokinetics measured as doseproportionality from 5 to 20 mg with normalized AUC values of 33–63 (× 10. h kg liter.). Despite its low bioavailability, the intra-individual changes in AUC after repeated drug intake are only 36%. No special recommendations for drug intake related to meals are necessary.
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