Titlebook: Next Generation Sequencing in Cancer Research, Volume 2; From Basepairs to Be Wei Wu,Hani Choudhry Book 2015 Springer International Publish

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Manar Samman M.Sc.,Neeraj Sethi M.B.Ch.B., M.R.C.S., D.O.H.N.S. of children. Fluoride also exhibits toxicity against terrestrial and aquatic animals, plants, and microorganisms. The presence of coexisting substances can modify the fluoride toxicity. A lot of compounds like arsenic, calcium, magnesium, aluminum, lead, and selenium have been investigated for thei

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Next-Generation Sequencing in the Era of Cancer-Targeted Therapies: Towards the Personalised Mediciancer-targeted therapies using the EGFR-targeted therapies as examples. It will further highlight the most common mechanisms of acquired drug resistance and will explain the experimental approaches to studying such mechanisms using the conventional biochemical and molecular techniques along with the

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Standardized Decision Support in NGS Reports of Somatic Cancer Variants,h community to have access to curated and up-to-date cancer pharmacogenomic associations. In addition, the community needs to remain cognizant of the potential consequences of misuse or overinterpretation of genomic data. Herein, I describe a systematic framework for variant annotation and prioritiz

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Next-Generation Sequencing for Cancer Biomarker Discovery, sequencing technology that enables sequencing of entire genomes or thousands of mutations simultaneously in a cost effective manner and hence can serve as a very powerful tool in biomarker detection and discovery. Many NGS-based studies published in the last few years have identified potential prog

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Validation and Implementation of Next-Generation Sequencing Technologies in a Clinical Molecular Di 46 cancer-related genes as an example, we have discussed various parameters which need to be established for validation and implementation of the NGS assays. We have highlighted various assay performance metrics which need to be established toward complete validation of the NGS platform before impl

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Next-Generation Sequencing Technologies and Formalin-Fixed Paraffin-Embedded Tissue: Application tont response..The major hurdle for NGS application to archival material is the effect of formalin fixation on nucleic acids. The process results in chemical modification, cross-linking, and fragmentation. Chemical modification can result in false-positive mutation calls, and fragmentation can result

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Applications of NGS to Screen FFPE Tumours for Detecting Fusion Transcripts,ch lead to low library complexity and mapping quality. It is important that bioinformatics tools are designed to address these challenges. Here we illustrate a framework to address them, using gFuse as the example. We present results by comparing the fusion transcripts discovered from analysis of RN

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,Integrative Analysis Identifies Transcription Factor–DNA Methylation Relationships and Introduces Nwith the recent accumulation of large-scale genomic data, has allowed for high-resolution in silico dissection of transcription factor–DNA methylation relationships. In this chapter, we present an integrative analysis of ENCODE (Encyclopedia of DNA Elements) ChIP-seq and DNase I hypersensitivity dat

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Small RNA Sequencing for Squamous Cell Carcinoma Research,ntly studying small noncoding RNAs in head and neck squamous cell carcinoma (HNSCC). Arising from epithelial cells in the lining of the upper aerodigestive tract and strongly associated with tobacco and alcohol consumption, HNSCC is among the leading cancers by incidence worldwide. Information on th