Titlebook: New Tide of Natural Product Chemistry; Hayato Ishikawa,Hiromitsu Takayama Book 2023 The Editor(s) (if applicable) and The Author(s), under

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Collective Synthesis of Monoterpenoid Indole Alkaloids Using Bioinspired Strategies in academia and industry. In this chapter, collective total syntheses of monoterpenoid indole alkaloids found in higher plants are highlighted. Secologanin and strictosidine, which are key branching intermediates in biosynthesis, were synthesized in gram-scale quantities. Then, 18 indole alkaloid s

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Total Syntheses of Densely Oxygenated Natural Products by Radical-Based Decarbonylative Convergent Ang intermolecular decarbonylative radical addition reactions to three kinds of unsaturated bonds (C=C, C=N, C=O) via radical exchange under redox neutral conditions. The feasibility of this synthetic strategy was verified by the expeditious and diastereoselective total syntheses of highly functional

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Marine Natural Products Targeting Tumor Microenvironment Chemical approach such as total synthesis, structure–activity relationship (SAR) study, and development of affinity probe opened the way to structure elucidation, in vivo evaluation, and target identification.

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A New Trend in Biosynthetic Studies of Natural Products: The Bridge Between the Amino Acid Sequence studies of fungal polyketides (PKs) based on the phylogenetic analysis of iterative polyketide synthases (iPKSs) and describes the chemical space of fungal PKs. A unified stereochemical rule contributing to the structural prediction and structure determination of fungal reduced PKs is also discussed.

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Total Syntheses of Densely Oxygenated Natural Products by Radical-Based Decarbonylative Convergent Athesis of densely functionalized natural products and pharmaceuticals. Moreover, as exemplified by the synthesis of polyoxins, these new synthetic strategies will accelerate the divergent total syntheses and detailed biological studies of natural products and related compounds to enhance their therapeutic utility.