Titlebook: New Therapies to Prevent or Cure Auditory Disorders; Sylvie Pucheu,Kelly E. Radziwon,Richard Salvi Book 2020 Springer Nature Switzerland A

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Review of Ototoxic Drugs and Treatment Strategies for Reducing Hearing Loss,ails the mechanisms underlying ototoxicity and provide potential strategies for reducing hearing loss. It is hoped that the information presented would prompt further studies into validating the efficacy of otoprotective agents described and provide the rationale for additional clinical studies in humans.

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iew of hair cell regeneration and identifies potential targeHearing loss is the most common form of sensory impairment in humans, affecting 360 million persons worldwide. In parallel, tinnitus disorder, the perception of a phantom sound often described as a ringing or buzzing, affects around 10–15%

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Book 2020ception of a phantom sound often described as a ringing or buzzing, affects around 10–15% of the general population and interferes with daily life. Hyperacusis, defined as a hypersensitivity to moderate-intensity sounds often co-occurs with tinnitus suggesting a common mechanism of dysfunction for t

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Noise-Induced Hearing Loss and Drug Therapy: Basic and Translational Science,ntification and treatment. The chapter includes discussion of the current state of these findings, their limitations, and avenues for further research. Finally, the chapter reviews current pharmacological interventions, their targeted pathways, and mechanisms of action that may hold promise for future treatment.

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Preclinical Animal Behavioral Models of Hyperacusis and Loudness Recruitment,dels. In this review, we discuss recent advances in the development of behavioral models that have been used to measure various forms of hyperacusis and the genetic models and experimental conditions that have been employed to induce hyperacusis in animals.

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Lifestyle Intervention to Prevent Age-Related Hearing Loss: Calorie Restriction,d nonhuman primates. This chapter reviews the current literature on interventions for age-related hearing loss (AHL), particularly focusing on a lifestyle-based intervention, CR, and what has been learned about the mechanisms underlying the beneficial effects of CR on auditory function in laboratory

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Immune System and Macrophage Activation in the Cochlea: Implication for Therapeutic Intervention,ar inflammatory activities in acute and chronic stress conditions and suggest that controlling the cochlear immune state could offer protection against not only ongoing pathogenesis but also future vulnerability in the event of additional stress. We highlight the potential functional roles of the im

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New Automatic and Robust Measures to Evaluate Hearing Loss and Tinnitus in Preclinical Models,collaboration between CILcare and Charles Coulomb Laboratory (L2C-BioNanoNMRI team). Tinnitus, a phantom auditory sensation, which occurs in the absence of an external sound stimulus, is generated presumably within the auditory brain. Here we focus on the inferior colliculus (IC), a midbrain structu