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Titlebook: New Strategies for Oral Immunization; International Sympos Jiri Mestecky (Professor of Microbiology),Jerry R. Conference proceedings 1989 T

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Oral Immunization with Sendai Virus in Miceimmunization. The concept of a common mucosal immune system is embodied in the observation that IgA B lymphocytes initially encountering antigen at one mucous membrane can, during their differentiation toward IgA-secreting plasma cells, migrate to other mucous membranes distant from the site of init
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Immunity to Rotavirusesndrome accounts annually for 3–5 billion cases and approximately 5–10 million deaths (Institute of Medicine 1985; Walsh and Warren 1979). Another estimate which reviewed data from several longitudinal studies in children revealed that 4.6 million diarrhea deaths and 744 million to 1 billion episodes
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Oral Immunization: Past and Presentatively, the intestinal tract is the most active organ engaged in immunoglobulin production and antibodies, particularly those of the IgA isotype, are selectively transported into the gut lumen (Conley and Delacroix 1987; Mestecky and McGhee 1987).
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Overview of the Mucosal Immune Systemmans; his observations indicated that bacterial agglutinins could appear in dysentery stools several days earlier than in the blood. The molecular basis for local immunity was established when Tomasi et al. (1965) confirmed that external secretions contained a unique immunoglobulin (Ig) subsequently called secretory IgA (SIgA).
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Biodegradable Microspheres: Vaccine Delivery System for Oral Immunizationo soluble staphylococcal enterotoxin B toxoid, oral immunization with enterotoxoid in microspheres induced circulating toxin-specific antibodies and a concurrent secretory IgA anti-toxin response in saliva and gut fluid.
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Immunity to Rotaviruses of diarrhea occurred in children less than 5 years of age in developing countries, excluding China (Snyder and Merson 1982). In developed countries diarrheal deaths occur infrequently but morbidity from diarrheal illness is high (Institute of Medicine 1986; Rodriguez et al. 1987).
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Conference proceedings 1989are in use for the immunization of animals as well as humans. This volume gives oral immunization the attention it deserves in light of recent methodological and technical advances in antigen delivery systems.
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