| 书目名称 | New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations |
| 编辑 | Xiangyu Chen |
| 视频video | http://file.papertrans.cn/666/665771/665771.mp4 |
| 概述 | Nominated by Chinese Academy of Sciences as an outstanding PhD thesis.Provides new methodologies of N-heterocyclic carbene catalysis.Describes in detail the annulation reactions of nitroalkenes, enals |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | .This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and α,β-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of β-substituted nitroalkenes. The scope of Rauhut–Currier reaction was successfully extended to the most challenging β-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via γ-addition. Highly enantiopure tetrahydropyridazinones and γ-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available α,β-unsaturated carboxylic acids were first successfully employed to generate the α,β-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.. |
| 出版日期 | Book 2017 |
| 关键词 | N-heterocyclic Carbenes; Organocatalysis; Annulations; Enantioselective synthesis; Heterocycles |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-10-2899-1 |
| isbn_softcover | 978-981-10-9734-8 |
| isbn_ebook | 978-981-10-2899-1Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer Nature Singapore Pte Ltd. 2017 |
|Archiver|手机版|小黑屋|
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