Titlebook: New Neuromuscular Blocking Agents; Basic and Applied As Dimitry A. Kharkevich (Professor and Chairman of t Book 1986 Springer-Verlag Berlin

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Steroid Derivativeslecules of particular interest. The use of a fairly fixed steroid skeleton to which reactive side chains are attached (. and . 1962) was an important step forward in the search for useful curarizing drugs and resulted in a very powerful competitive acetylcholine antagonist, pancuronium (. and . 1966

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The Derivatives of Carboxylic Acidsds. The reason for this is that they are hydrolyzed in the organism, the duration of their action being, therefore, limited. Since succinylcholine was found to possess neuromuscular blocking activity and was widely adopted into medical practice, a great number of quaternary salts of ester derivative

Coronation

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Delphinium Alkaloidsher regions of the USSR. These plants are known to be poisonous; animals eating them show the effects of poisoning, the symptoms of muscle relaxation being predominant. As far back as the beginning of the nineteenth century, a crystalline base called delphinine (C.H.O.N) was isolated from . L. Later

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major conceptual papers, review articles, and books. Dews (1955), Sidman (1955), and Brady (1956) published some of the first methodologically significant papers, changing the way both psychologists and pharmacologists viewed the analysis of the behavioral actions of drugs. Dews and Morse (1961), Co

GNAT

D. A. Kharkevichnotions of central nervous systems as being structurally static after development are giving way to conceptualizations involving reorganization of the participating elements as function demands. All aspects of nervous systems should perhaps be thought of as at least having the potential for change a

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L. P. Wennogleory activity of neurons. The importance of peptides in the control of neural function is underscored by the growing research in four different areas: (a) co-localization of peptides with classical neurotransmitters (Lundberg and Hökfelt 1983; Lloyd et al. 1987); (b) demonstration of peptidergic neur

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ocal reactions, large local reactions, systemic reactions, toxic reactions, and unusual reactions. Mastocytosis is an important risk factor for systemic reactions, and antihypertensive medications may increase the severity of systemic reactions. Susceptible individuals mount a Th2 immune response le

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