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Titlebook: New Horizons in Allergy Immunotherapy; Alec Sehon,Kent T. HayGlass,Dietrich Kraft Book 1996 The Editor(s) (if applicable) and The Author(s

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,Mechanisms of Allergic Bronchoconstriction in the Rat✲, by inhalation of allergen and the underlying immunobiology of the reaction to allergen. The Brown Norway (BN) rat has been extensively characterized and appears to be among the best models thus far described, showing high levels of specific immunoglobulin E (IgE) on active sensitization (9,15), ear
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Glutathione S-Transferase Induces Murine Dermatitis that Resembles Human Allergic Dermatitis,ly history of atopic disease. The incidence of atopic dermatitis, like asthma, has been increasing.1 Larsen . found that the cumulative incidence rate of atopic dermatitis in children up to 7 years of age increased from 3% in the cohort born between 1960 and 1964 to 10% in the cohort between 1970 an
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Effects of rIL-12 Administration on an Antigen Specific Immune Response,IgG. production; whereas, T.2-like responses are dominated by IL-4, IL-10, IgG, and often IgE. IL-12 has been reported to promote T.l-like responses . among naive T cells (1) and to stimulate both T.l (2) and T.2 (3) clones to produce IFNγ, although the latter was determined to be transient. In addi
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Mapping the Genes for IgE Production and Allergy,, are complex. First, allergy is ., that is to say, the expression of the disease is influenced by interactions between multiple major and minor genes as well as by non-genetic factors such as the degree of allergen exposure. Second, like many other complex human diseases, allergy is likely to be .
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Regulation of Interleukin-12 Signalling During T Helper Phenotype Development,e 1 (Thl) phenotype is characterized by high levels of interferon-γ (IFNγ) and lymphotoxin production. Thl development stimulates cell-mediated immune responses, including macrophage activation, and the production of restricted immunoglobulin isotypes such as IgG2a (3). The Th2 phenotype correlates
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