Titlebook: New Generation Vaccines; The Role of Basic Im Gregory Gregoriadis,Brenda McCormack,George Poste Book 1993 Springer Science+Business Media N

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Cornelis A. Kraaijeveld,Tom A. M. Oosterlaken,Harm Snippeay to reduce thermal conductivity is to increase porosity of the material, the contribution of solid phase can be diminished by this manner. This principle is used for manufacture of most of thermal insulators such as widespread polymer and inorganic foams. They are characterized by extremely low th

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The Multiple Accessory Cell Concept: Its Relevance to the Development of Adjuvants and Vaccines,ction of the antibody response and for the generation of immunological memory. These cells have a crucial function in the processing and/or presentation of antigens to lymphoid cells. For that reason, they have to be considered one of the most obvious targets in the development of adjuvants and vacc

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Carriers for Peptides: Theories and Technology,me) which contain the necessary B- and T-cell epitopes for immunogenicity .. However, there is little doubt that carrier proteins still offer the most straightforward and convenient way of presenting poorly immunogenic peptides to the immune system. This may be achieved either by chemical linkage of

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Co-Entrapment of T-Cell and B-Cell Peptides in Liposomes Overcomes Genetic Restriction in Mice and s (Gregoriadis et al, 1991). The latter, used extensively since 1970 as a drug delivery system (Gregoriadis and Florence, 1993), were shown in 1974 (Allison and Gregoriadis, 1974) to promote immune responses to entrapped diphtheria toxoid. Work by numerous workers during the last two decades (Gregor

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Initiation of Immune Response with ISCOM,duce replicating or non-replicating antigens. Promising results were e.g. obtained with vaccinia as a replicating virus vector and with salmonella as a bacterial vector producing cloned antigens. Generally, non-replicating purified antigens are poorly immunogenic regardless of whether they are isola

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