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Titlebook: New Frontiers of MR-based Techniques in Multiple Sclerosis; Massimo Filippi,Giancarlo Comi Book 2003 Springer-Verlag Italia, Milano 2003 M

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Introduction,ur ability to diagnose this condition and to monitor its evolution. The exquisite sensitivity of T2-weighted MRI in the detection of MS lesions, together with the ability of postcontrast T1-weighted images to reflect the presence of increased blood-brain barrier (BBB) permeability associated with in
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Diffusion-Weighted MRI,t important limitations. First, MRI lacks specificity with regard to the heterogeneous pathological substrates of individual lesions, and in consequence does not allow tissue damage to be quantified. Edema, inflammation, demyelination, remyelination, gliosis, and axonal loss [1] all have a similar a
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Perfusion MRI,f the organ. It is an important indicator of tissue health and viability as it offers an insight into the efficiency of delivery of nutrients and removal of waste products, and is measured in millilitres of blood per gram of tissue per unit time. As the brain receives a significant proportion of tot
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Functional MRI,stations and a highly variable evolution. During the past decade, significant efforts have been devoted to improving our understanding of the pathophysiology of MS, with the ultimate goal of identifying and monitoring treatment strategies that have the potential to modify the evolution of the diseas
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perate in a network where one of its nodes . is hostile (contaminated) in the following way: when . is visited by an agent, it is decontaminated, the agent vanishes without leaving any trace, and all adjacent nodes of . which are unoccupied by agents are now contaminated. The goal is to find the min
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