Titlebook: New Frontiers in the Study of Gene Functions; George Poste,Stanley T. Crooke Book 1987 Plenum Press, New York 1987 Chromosom.DNA.Escherich

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Regulation of the Heat-Shock Response in Escherichia coli, Schlesinger .., 1982). This response is called the ., and the proteins synthesized in response to heat stress are called the . (HSPs). Both prokaryotes and eukaryotes have been shown to have a heat-shock response (Schlesinger .., 1982). At least two of the HSPs are strongly conserved between prokar

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DNA Supercoiling as a Regulator of Bacterial Gene Expression,e ways in which these factors interact with each other. Such factors include not only the specific proteins that bind to regulatory sites on DNA, but also more subtle aspects of DNA structure, such as local bending, Z-DNA regions, and palindromic sequences.

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Retrotransposition in Yeast,an element at a new chromosomal site. The structure of Ty elements is similar to that of the endogenous proviruses found in vertebrates (Clare and Farabaugh, 1985; Mount and Rubin, 1985). Each element contains a large central portion of approximately 5.2 kilobases flanked by direct repeats of about

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Comparative Genetic Analysis of Homeobox Genes in Mouse and Man,nes that have developmental functions. The homeobox sequences are conserved in many animal groups across the protostome and deuterostome lineages of evolutionary ascent. Highly conserved homeobox sequences have been described in numerous vertebrates, including amphibians and mammals (McGinnis .., 19

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Specificity of Gene Expression and Insertional Mutagenesis in Transgenic Mice,alian organism. A wide variety of gene constructs have been inserted in the mouse germ line, and the initial data compiled with this system have recently been reviewed by Gordon and Ruddle (1985) and by Palmiter and Brinster (1985). One of the most important conclusions from this initial work has be

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Retroviruses as Insertional Mutagens,and tagging of a gene. In mammals, two approaches have been successful in inducing insertional mutants: Transgenic animals have been generated by inserting either retroviruses or recombinant DNA into the germ line. Experiments with the first approach exposed mouse embryos to retroviruses at differen