Titlebook: New Experimental Modalities in the Control of Neoplasia; Prakash Chandra Book 1986 Springer Science+Business Media New York 1986 AIDS.biol

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Terminal Transferase and Adenosine Deaminase Activities in Human Neoplasia: Their Role in Modulatinage of the disease and the cell types involved in human leukemia B cell proliferation and severe combined immune deficiency syndrome (SCID). The use of these biological markers has been very useful in selecting treatment protocols for patients with leukemia/lymphoma and SCID.

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J. R. Bertino,S. Srimatkandada,M. D. Carman,M. Jastreboff,L. Mehlman,W. D. Medina,E. Mini,B. A. Moro

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Oncogenes and Tyrosine Kinase Activities as a Function of the Metastatic Phenotype,lones of two murine tumors, the Lewis lung carcinoma and the T10 sarcoma (9–12). Are the immunogenic properties the only one to play a role in the metastatic phenotype or do other mechanisms play a role in the metastatic process of these two tumors? To explore additional components which control the

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T-Cell Growth Factor (Interleukin-2),y from normal peripheral blood lymphocytes and also from gibbon and human leukemic cell lines (10–13). cDNAs encoding this lymphokine have been isolated and sequenced (10,14,15) and the IL-2 gene characterized (16–17). The IL-2 gene has been localized to chromosome 4q (18).

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Mechanisms of Membrane-Mediated Cytotoxicity by Adriamycin,alkylating agents) or by interference with DNA biosynthesis (e.g. anti-metabolites). The major limitation of this approach is lack of selectivity because normal, non-cancer cells also have DNA, and this DNA and its synthesis are only imperceptibly (to a drug) different than the DNA of tumor cells. A

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