Titlebook: New Developments in Antirheumatic Therapy; K. D. Rainsford,G. P. Velo Book 1989 Kluwer Academic Publishers 1989 Arthritis.drug.drug develo

intuition

The T cell as a therapeutic target, an infectious aetiology or a pathognomonic immune abnormality, these diseases are characterized as being autoimmune. Rheumatoid arthritis, systemic lupus erythematosus, myasthenia gravis and multiple sclerosis are all well-known examples. An important therapeutic approach to these diseases is the selective inhibition of immune activity.

Glycogen

Recent developments in antirheumatic therapy,This chapter will discuss recent developments in anti-rheumatic therapy and serve as an introduction to later chapters in which a variety of novel therapeutic approaches will be discussed in more detail, including topics from newer avenues of immunomodulation to alternative methods of drug delivery.

柔软

Gold(I)-thiolates: slow-acting anti-arthritic drugs,Chrysotherapy, the current use of gold-containing drugs to treat rheumatoid disease, presents many problems — some intriguing, others quite vexing:

Iniquitous

Superoxide dismutase modifications for anti-inflammatory therapy,In the early 1960s a metalloprotein with anti-inflammatory properties in man and animals was isolated from bovine liver., which was, some years later identified as superoxide dismutase (SOD). This is a copper-zinc protein which has subsequently been purified and characterized by McCord and Fridovich..

伸展

生命层

MAG

Animal models of arthritic disease: influence of novel compared with classical antirheumatic agentsthese crippling afflictions. Unfortunately this is not yet totally so, and our existing models of arthritis are frequently criticized for both their failure to replicate the human condition, and to reliably demonstrate the disease-modifying qualities of gold and penicillamine, the mainstays of human

果仁

Novel eicosanoid inhibitors,ver 50 years ago. We now know that AA can be transformed into not just prostaglandins (PGs) and thromboxanes (TxB.) but also 5-lipoxygenase (5-LO) products collectively termed leukotrienes (LTs). Whether all the metabolites of AA have been identified is uncertain and the recent discovery of lipoxins

Thymus

New steroidal anti-inflammatory drugs,pment of local corticosteroids. Two synthetic approaches have been dominant: a traditional means of increasing lipophilicity of potent corticosteroids by masking the hydroxyl group and synthesis of non-systemic steroids by introducing metabolically labile functional groups. The slow increase in the

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