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Titlebook: New Concepts in the Pathogenesis of NIDDM; Claes Göran Östenson,Suad Efendić,Mladen Vranic Book 1993 The Editor(s) (if applicable) and The

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书目名称New Concepts in the Pathogenesis of NIDDM
编辑Claes Göran Östenson,Suad Efendić,Mladen Vranic
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: New Concepts in the Pathogenesis of NIDDM;  Claes Göran Östenson,Suad Efendić,Mladen Vranic Book 1993 The Editor(s) (if applicable) and The
描述The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia­ betes research, hoping that this type of interaction may result in new concepts and treat­ ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in
出版日期Book 1993
关键词Diabetes; Diabetes mellitus; Insulin Secretion; Pathogene; development; insulin; metabolism
版次1
doihttps://doi.org/10.1007/978-1-4615-2910-1
isbn_softcover978-1-4613-6262-3
isbn_ebook978-1-4615-2910-1Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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Regulation of Adipose Tissue Lipolysis, Importance for the Metabolic Syndromeliver, where they are used as substrate for esterification to triglycerides and incorporation into lipoproteins. Small changes in the turnover rate of free fatty acids in adipose tissue may in the long-term cause marked alterations of triglycerides in plasma and in adipose tissue leading to hypertriglyceridemia and/or obesity.
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0065-2598 s early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories
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Indirect Effects of Insulin in Regulating Glucose Fluxesmany of the known effects of insulin on glucose metabolism may be exerted partially via indirect pathways.. Cumulative evidence indicates that the indirect actions of insulin not only contribute to, but sometimes may play a predominant role in the overall effects of insulin on glucose fluxes.
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Substrates and the Regulation of Hepatic Glycogen Metabolismogen stores are depleted (Duderman, 1975). The processes of glycogen formation and glycogenolysis are controlled by the activity of glycogen synthase and phosphorylase which, in turn, are subject to finely-tuned regulatory mechanisms (eg. Hers, 1976; van de Werve and Jeanrenaud, 1987; Nuttall et al., 1988).
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On Insulin Action in Vivo: The Single Gateway Hypothesisnsible for insulin resistance, and given its potential importance in the pathogenesis of chronic disease, it is incumbent upon us to continue to try to identify the cellular or molecular defects which underlie this condition.
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