Titlebook: New Concepts in Pathology and Treatment of Autoimmune Disorders; C. Pozzilli,P. Pozzilli,J.-F. Kapp Conference proceedings 2001 Springer-V

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New Concepts in Pathology and Treatment of Autoimmune Disorders

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Microarray Technology in the Pathogenesis and Management of Autoimmune Disorders, offer the first glimpse into the future of organizing and using this type of information. Investigators can simultaneously monitor the RNA levels of a large number of genes, or even the entire genome, in the context of their biological system.

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,Specific Immunotherapy of Multiple Sclerosis by Altered Peptide Ligands — Risk or Benefit?,tor (TNF)-α/β [9–11]. Furthermore, they often recognize epitopes similar to those identified as encephalitogenic in animals and frequently are restricted by MS-associated HLA-DR molecules such as HLA-DRB 1*1501 or -DRB5*0101 [12–15]. However, such autoreactive T cells have also been isolated from he

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New Strategies in Clinical Islet Cell Transplantation,than exogenous insulin, since islets function for an entire lifetime, produce their own insulin, release it in a perfectly timed fashion and keep blood sugar levels in the normal range thanks to a built-in “glucose sensor” [5]. Currently, whole organ pancreas transplantation is an islet-replacing pr

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Multiple Sclerosis Perspective,ence classified among the multifactorial diseases). Classical epidemiological observations have suggested the existence of environmental and genetic influences, active at the population level, for both MS and IDDM, with some similarities between the two diseases (i.e. the high prevalence of both MS

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Type 1 Diabetes and Multiple Sclerosis: Similarities and Dissimilarities,ting in a genetically susceptible individual with the generation of an autoimmune response towards beta cells ultimately culminate in the onset of hyperglycaemia [1–3]. In different individuals the process that leads to beta cell destruction may vary, being under the effect of different genetic, env

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,Specific Immunotherapy of Multiple Sclerosis by Altered Peptide Ligands — Risk or Benefit?, in which autoreactive CD4. T cells are considered to play a crucial role [3–5]. In different forms of experimental autoimmune encephalomyelitis (EAE), which serves as an animal model of MS, a number of myelin, glial components, and even heat-shock antigens can serve as targets for the encephalitoge