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Titlebook: New Challenges for Cancer Systems Biomedicine; Alberto d’Onofrio,Paola Cerrai,Alberto Gandolfi Book 2012 Springer-Verlag Italia Srl. 2012

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书目名称New Challenges for Cancer Systems Biomedicine
编辑Alberto d’Onofrio,Paola Cerrai,Alberto Gandolfi
视频video
概述State of the art in tumor modelling.It stresses the role of biomedical scientists working in modelling.Original interdisciplinary insight into the biomedical applications.Includes supplementary materi
丛书名称SEMA SIMAI Springer Series
图书封面Titlebook: New Challenges for Cancer Systems Biomedicine;  Alberto d’Onofrio,Paola Cerrai,Alberto Gandolfi Book 2012 Springer-Verlag Italia Srl. 2012
描述.The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics. .
出版日期Book 2012
关键词Mathematical Oncology; Systems Biology; Systems Biomedicine; Tumor; partial differential equations
版次1
doihttps://doi.org/10.1007/978-88-470-2571-4
isbn_softcover978-88-470-5617-6
isbn_ebook978-88-470-2571-4Series ISSN 2199-3041 Series E-ISSN 2199-305X
issn_series 2199-3041
copyrightSpringer-Verlag Italia Srl. 2012
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Dynamic Simulations of Pathways Downstream of TGF,, Wnt and EGF-Family Growth Factors, in Colorectalferent specifically altered onco-proteins affected by excess of function. The dynamic behavior of the simulation seems quite reasonable, in terms of what is known about the physiology and the pathology of this signaling-network region. Preliminary experimental verification experiments look encouraging.
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Spatio-Temporal Modelling of Intracellular Signalling Pathways: Transcription Factors, Negative Feedters such that sustained oscillatory dynamics occur, consistent with available experimental measurements. In order to bridge the gap between . and . experiments we investigate more realistic cell geometries by using an imported image of a real cell as our computational domain.
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Glucose Metabolism in Multicellular Spheroids, ATP Production and Effects of Aciditymors. The last part of the paper is devoted to the phenomenon of acid mediated tumor invasion, which exploits the different resistance to acidity of tumor and of normal cells. In particular, a one dimensional model is discussed in which invasion takes the form of a travelling wave front.
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Cell-Cell Interactions in Solid Tumors — the Role of Cancer Stem Cells model and a cellular Potts model. Simulations of tumor growth with both techniques reveal that cancer stem cell-driven solid tumors grow as conglomerates of self-metastases, suggesting a robust biological phenomenon. The growth rate of the tumor is dependent on the complex interplay of the underlying model parameters.
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