Titlebook: New Aspects of Hypertrophic Cardiomyopathy; Morphology, Mechanis M. Kaltenbach,R. Hopf,B. Kunkel Conference proceedings 1988 Dr. Dietrich S

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Evidence for true obstruction to left ventricular outflow in obstructive hypertrophic cardiomyopathyrimary disorder of heart muscle in which the site and extent of the hypertrophic process are believed to be of importance in determining the disease manifestations (30). In this discussion we will limit our remarks to the commonest form of HCM, that is associated with ventricular (asymmetrical) sept

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Dynamic obstruction to left ventricular outflow: The case for its existence in hypertrophic cardiomyf this disease for over 25 years, and while generally regarded as a prominent and important component of HCM, its clinical and pathophysiologic significance has been the source of periodic and often intense disagreement and controversy (1–20). In the early 1960s, a number of investigators observed t

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Influence of verapamil on diastolic left ventricular function in myocardial hypertrophy of differentis effect was attributed to improved left ventricular relaxation and increased early diastolic filling (1, 4–8). The mode of action of the calcium-blockers is, however, not clear, but certainly involves an inhibition of the calcium influx into the muscle cell. A reduction in intracellular cytosolic