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Titlebook: New Approaches to Drug Discovery; Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch Book 2016 Springer International Publishing Switzerland 201

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,New Compound Classes: Protein–Protein Interactions,f success stories in small-molecule PPI inhibition and natural-product PPI stabilization increasingly encourage academia and industry to invest in PPI modulation. In this chapter examples of both inhibition as well as stabilization of PPIs are reviewed including some of the technologies which has been used for their identification.”
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Functional Genomics in Pharmaceutical Drug Discovery,discussed with its advantages and challenges in this chapter. Furthermore the potential of CRISPR/Cas9, a gene-editing method that has recently been adapted for use as functional screening tool, will be briefly reviewed.
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