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Titlebook: New Approaches in Eukaryotic DNA Replication; A. M. Recondo Book 1983 Plenum Press, New York 1983 DNA.Elongation.Termination.attention.can

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发表于 2025-3-21 19:03:29 | 显示全部楼层 |阅读模式
书目名称New Approaches in Eukaryotic DNA Replication
编辑A. M. Recondo
视频video
图书封面Titlebook: New Approaches in Eukaryotic DNA Replication;  A. M. Recondo Book 1983 Plenum Press, New York 1983 DNA.Elongation.Termination.attention.can
描述DNA replication in eukaryotes is an important field, particular­ ly because of its direct impact on the study of cancer. The under­ standing of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins which participate in replication of DNA in eukaryotic cells have been identified, isolated and characterized. New concepts in chromatin structure have refocused attention on the study of replication of DNA complexed with his tones and non-histone chromosomal proteins. However, progress has been noticeably slower than for prokaryotes, essentially because of the difficulty in genetic analysis of eukaryo­ tic DNA replication. In June 1980, a workshop was organized in Cargese, Corsica (France) to facilitate exchanges of information between workers spe­ cializing in prokaryotes and those specializing in eukaryotes, and to allow discussion of new experimental approaches. With this in mind, special interest has been taken in the origin and termination of ch
出版日期Book 1983
关键词DNA; Elongation; Termination; attention; cancer; cells; chromosome; enzymes; lead; proliferation; protein; prot
版次1
doihttps://doi.org/10.1007/978-1-4684-4397-4
isbn_softcover978-1-4684-4399-8
isbn_ebook978-1-4684-4397-4
copyrightPlenum Press, New York 1983
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发表于 2025-3-21 21:48:26 | 显示全部楼层
Topology, Type II DNA Topoisomerases and DNA Replication in Prokaryotes and Eukaryotesughter duplexes avoided? Which mechanism generates the interlocked DNA rings found in several organisms? iii) What is the role of negative supercoiling of natural DNAs in their replication if any? iv) How is DNA unwinding compatible with the nucleosomal and the supranucleosomal organization of the chromosome?
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A Mutation that Blocks Initiation of DNA Synthesis in Hamster Cellsve temperature the rate of DNA chain elongation is not reduced. Initiation is decreased as shown by an increase in the intervals between active replication origins and a decrease in the relative frequency of initiation events immediately after shift to nonpermissive temperature.
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Enzymatic Mechanisms in DNA Replication: Initiation of Strandsy the ⌽X-encoded gene A protein, of the viral strand, thereby initiating continuous elongation of this strand. When fully restored by the addition of protein i, the primosome repeatedly primes the discontinuous elongation of the complementary strand through several cycles of progeny RF production.
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of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins
发表于 2025-3-23 06:24:48 | 显示全部楼层
DNA Chain Elongation Mechanism of DNA Polymerases α, β and γThere are many lines of evidence that indicate the existence of at least two kinds of DNA replication mechanisms in eukaryotic cells.
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