Titlebook: New Approaches for Antifungal Drugs; Prabhavathi B. Fernandes Book 1992 Springer Science+Business Media New York 1992 drugs.pharmaceutical

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Antifungal Proteins from Plants: A Possible New Source of Human Therapeutics,ons is that fungi and their eukaryotic hosts are surprisingly similar. One of the main tenants of chemotherapy and drug discovery groups is to exploit a biochemical difference between the host and the pathogen. Several drugs currently in use capitalize on differences in membrane sterols (polyene ant

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,Elongation Factor 3 — A Unique Fungal Protein,y in the fungal family. The translational machinery of yeast is nonfunctional without this protein. A physical analog of EF-3 is absent in higher eukaryotes. Extensive knowledge of the structure and function of this unique yeast protein and comparative structural analyses of EF-3 with other eukaryot

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Genetic Approaches to Antifungal Drug Discovery,s aspects of the biology and genetic regulation of cellular processes in these lower eukaryotes. The cloning and analysis of genes and their products has led to a large body of data that allows comparison of key molecules in fungi with their counterparts in vertebrate species. To a great extent, a s

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Sterol 14,-Demethylase: Target of the Azole Antifungal Agents,to be potent inhibitors of a wide variety of fungi that have membrane sterols. However, a number of challenges remain as novel fungal infections occur in immunocompromised patients and with the occurrence of disease resistance. The latter is currently more pronounced as a problem in agriculture, but

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Sterol 14,-Demethylase: Target of the Azole Antifungal Agents,e of the azole antifungals has been apparent for more than 20 years the molecular details of tolerance and mode of action are only now becoming clearly defined. Many of these phenomena are now amenable to modern molecular analysis and should allow these studies to be completed.

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Amphotericin B Phospholipid Formulations,g, and hypotension have been reported to occur during infusion of the drug while chronic effects such as renal toxicity, hypokalemia, and hypomagnesemia have been reported (Cheng et al., 1982; Lopez-Berestein et al., 1987).

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