Titlebook: Neurotransmitter Transporters; Harald H. Sitte,Michael Freissmuth Book 2006 Springer-Verlag Berlin Heidelberg 2006 Associated Proteins.Gen

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The Dopamine Transporter: A Vigilant Border Control for Psychostimulant Action,ral properties of psychostimulants for nearly three decades. The primary means by which dopamine transmission in the synapse is terminated is via the dopamine transporter (DAT), the presynaptic plasmalemmal protein that is responsible for the reuptake of released dopamine. Numerous abused as well as

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Oligomerization of Neurotransmitter Transporters: A Ticket from the Endoplasmic Reticulum to the Pls from the synaptic cleft, these transporters terminate signalling and affect duration and intensity of neurotransmission. Thus, a lot of work has been invested in the determination of the cellular compartment to which neurotransmitter transporters localize. In particular, the polarized distribution

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Regulation of Vesicular Monoamine and Glutamate Transporters by Vesicle-Associated Trimeric G Proteterminals or in secretory vesicles by the activity of specific transporters of the plasma and the vesicular membrane, respectively. In the central nervous system the postsynaptic response depends—amongst other parameters—on the amount of neurotransmitter stored in a given vesicle. Neurotransmitter p

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Human Genetics and Pharmacology of Neurotransmitter Transporters,redby transporters into presynaptic neurons, a major mode of their inactivation in the brain. Genetic studies of human biogenic amine transporter genes, including the dopamine transporter (hDAT; .), the serotonin transporter (hSERT; .), and the norepinephrine transporter (hNET; .) have provided insi

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ADHD and the Dopamine Transporter: Are There Reasons to Pay Attention?,. The presynaptic DA transporter (DAT) inactivates DA following release and provides a route for non-exocytotic DA release (efflux) triggered by amphetamines. The synaptic role of DATs first established through antagonist studies and more recently validated through mouse gene-knockout experiments, r

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Inactivation of 5HT Transport in Mice: Modeling Altered 5HT Homeostasis Implicated in Emotional Dys of human behavioral and psychiatric disorders but are also fundamental in the development novel therapeutic strategies. As an example, inactivation of the serotonin (5HT) transporter (.) gene in mice expanded our view of adaptive 5HT uptake regulation and maintenance of 5HT homeostasis in the devel

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