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Titlebook: Neurotoxic Factors in Parkinson’s Disease and Related Disorders; Alexander Storch,Michael A. Collins Book 2000 Springer Science+Business M

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Isoquinolines in Parkinson’s Disease parkinsonogenic compounds. TIQ, l-benzyl-l,2,3,4-tetrahydroisoquinoline (1-benzyl-TIQ) could induce parkinsonism in rodents and a primate. Deprenyl, an anti-parkinsonian agent can reduce 1-benzyl-TIQ content in brain. On the other hand, we have also detected TIQ derivative, l-methyl-l,2,3,4-tetrahy
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Systematic Studies of Dopamine and Dopamine-Derived Salsolinol and Norsalsolinol levels in Various H-active compounds might be formed endogenously during the establishment of alcohol addiction (Huber and Melzig, 1992). This theory was supported by the proof of . formation of various alkaloids in the human body. One hypothesis invoked the ethanol metabolite acetaldehyde as a critical intermediate i
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,-Methyl-,-Carbolinium Neurotoxins in Parkinson’s Diseasequentially forming 2-mono-[.]-methylated and 2,9-di-[.’]-methylated .-carbolinium cations. These .-methylated .-carbolinium cations are structural analogs of MPP. with a nitrogen bridge. Because of their similar neurotoxicity to MPP., they could be underlying factors in idiopathic Parkinson’s diseas
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