Titlebook: Neurosecretion: Secretory Mechanisms; José R. Lemos,Govindan Dayanithi Book 2020 Springer Nature Switzerland AG 2020 Neuroendocrine neuron

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Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic B granule exocytosis suggest the dual roles of Ca. in insulin secretion: to trigger acute exocytosis directly and to maintain sustained insulin secretion via cAMP/PKA. Here, we briefly summarize the roles of Ca., cAMP/PKA, and adenylyl cyclase in glucose/GLP-1-mediated insulin secretion and the unique method used in these studies.

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How Do Bacterial Neurotoxins Affect Neurosecretion?,icle/granule intracellular traffic and secretion processes, we address several examples of key bacterial cytotoxins affecting their cellular functions. We also briefly comment on the action of a few bacterial toxins that potentiate release of neurotransmitters.

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Neurosecretion: A Historical Overview,eir insights that this cell type possessed the characteristics of both endocrine cells and neurons are presented. A fundamental feature of the neurosecretory cell, also referred to as a neuroendocrine cell, is the presence of many large dense core vesicles (neurosecretory vesicles) in its cytoplasm.

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Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals,ls in the posterior pituitary (neurohypophysis), are a classical example of a neuroendocrine system. This hypothalamic-neurohypophysial system (HNS) has proven to be an important model for understanding the organization of neuronal Ca. homeostasis and mechanisms of neurosecretion. The MCNs synthesiz

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Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus,ess and acts as an anxiolytic factor. Recent studies revealed higher levels of OT release in hypothalamus culture isolated from subordinate mice in group-housed males than in that from dominant mice after cage-switch stress. OT concentrations in micro-perfusates at the paraventricular nucleus upon p

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Somato-Dendritic Secretion of Neuropeptides,to synaptic transmission, somato-dendritic secretion is best characterized as modulating the overall excitability of the target cells over a longer time course via actions at presynaptic and extrasynaptic receptors. Magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei synt

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