Titlebook: Neuropilin; From Nervous System Dominique Bagnard Book 2002 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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The Function of Neuropilin/L1 Complex,ty of clinical signs associated with the X-linked recessive neurological disorder that is caused by mutations in the Ll gene. LI regulates the formation of axon fascicles and promotes neurite outgrowth through interaction with a wide spectrum of binding partners including cell adhesion molecules and

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Neuropilin and Class 3 Semaphorins in Nervous System Regeneration,lure of injured CNS axons to regenerate is thought to be caused, in part, by neurite outgrowth inhibitory factors expressed in and around the lesion. These include several myelin associated inhibitors, proteoglycans, and tenascin-R. Recent studies have documented the presence of class 3 semaphorins

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0065-2598 d according to the nature of adhesion molecules that are expressed on the cell surface. The identifica­ tion of several families of adhesion molecules, well conserved throughout evolu­ tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish func

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Neuropilin-1 in the Immune System, neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. These results emphasize the molecular similarities between the nervous and the immune systems and open new areas in the modulation of the immune response.

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Neuropilin and Its Ligands in Normal Lung and Cancer,ced and SEMA3F protein is delocalized from the membrane to the cytoplasm. In lung cancers, SEMA3F staining correlates inversely with tumor stage with high SEMA3F associated with less aggressive tumors. Conversely, more aggressive tumors are associated with increased VEGF staining and a corresponding loss in membranous SEMA3F.

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