Titlebook: Neuropharmacology of New Psychoactive Substances (NPS); The Science Behind t Michael H. Baumann,Richard A. Glennon,Jenny L. Wil Book 2017 S

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MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State andor stimulants enhance metabolism and increase body temperatures, their use under conditions of physiological activation and in warm humid environments could result in pathological hyperthermia, a life-threatening symptom of acute drug intoxication. Here, we will describe the brain hyperthermic effec

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Pharmacological and Toxicological Effects of Synthetic Cannabinoids and Their Metabolites,l” alternatives to cannabis, reports indicate that SCBs induce toxicity not often associated with the primary psychoactive component of marijuana, Δ9-tetrahydrocannabinol (Δ.-THC). This chapter will summarize the evidence that use of SCBs poses greater health risks relative to marijuana and suggest

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,Pharmacology and Toxicology of ,-Benzylphenethylamine (“NBOMe”) Hallucinogens,ptor activation. One class of hallucinogens are 2,5-dimethoxy-substituted phenethylamines, such as the so-called 2C-X compounds 2,5-dimethoxy-4-bromophenethylamine (2C-B) and 2,5-dimethoxy-4-iodophenethylamine (2C-I). Addition of an .-benzyl group to phenethylamine hallucinogens produces a marked in

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,Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure–Activity Relate in rats. Subsequent modeling studies implicated specific amino acids in DAT and SERT that might interact with 4-substituent volume to determine effects produced by this series of cathinone analogs. These studies illustrate use of QSAR analysis to investigate pharmacology of cathinones and function of monoamine transporters.