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Titlebook: Neurological Adverse Reactions to Anticancer Drugs; Jerzy Hildebrand Conference proceedings 1990 Springer-Verlag Berlin Heidelberg 1990 An

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书目名称Neurological Adverse Reactions to Anticancer Drugs
编辑Jerzy Hildebrand
视频video
丛书名称ESO Monographs
图书封面Titlebook: Neurological Adverse Reactions to Anticancer Drugs;  Jerzy Hildebrand Conference proceedings 1990 Springer-Verlag Berlin Heidelberg 1990 An
描述In this timely and up-to-date book, the latest knowledge on neurological syndromes due to neurotoxicity of antineoplastic drugs is presented. The initial chapters discuss the following vital topics: - the importance of blood-brain barrier changes in cancer patients, - laboratory and clinical studies on the neurotoxicity of anticancer drugs, - and the role of cumulative toxicity of radiation therapy and chemotherapy. Clinical presentation and diagnosis of various neurological conditions related to antineoplastic chemotherapy are then also thoroughly discussed. Indispensable to the neuro-oncologist and useful to all physicians managing cancer patients, this book is a valuable source of current information.
出版日期Conference proceedings 1990
关键词Antineoplastic drugs; cancer; chemotherapy; nervous system; neurotoxicity; oncology; physiology; radiation
版次1
doihttps://doi.org/10.1007/978-3-642-76142-3
isbn_softcover978-3-642-76144-7
isbn_ebook978-3-642-76142-3
copyrightSpringer-Verlag Berlin Heidelberg 1990
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Conference proceedings 1990ial chapters discuss the following vital topics: - the importance of blood-brain barrier changes in cancer patients, - laboratory and clinical studies on the neurotoxicity of anticancer drugs, - and the role of cumulative toxicity of radiation therapy and chemotherapy. Clinical presentation and diag
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Acute Meningeal Reaction, severe clinical manifestation of this chemical arachnoiditis occurs 2 to 4 hours after intrathecal injection of MTX. Meningism is rarely seen after a first administration of MTX, but incidence increases with the number of intrathecal injections and is dose related [2].
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Cerebellar Disorders,nly the cerebellar toxicity of antineoplastic and related agents, but also other important causes of cerebellar dysfunction occurring in patients with cancer. A recent monograph reviews cerebellar physiology and its disorder [1].
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Acute Encephalopathy and Seizures,ress to stupor or coma. Focal neurological signs such as aphasia or hemiparesis may or may not accompany the delirium. Focal signs in the absence of delirium are not considered here. Encephalopathy and seizures may occur either together or separately and may be caused directly or indirectly by several antineoplastic agents.
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Chronic Encephalopathies,ike the chronic delayed effects of RT, they may occur when the patient is still being treated with the drug. In this chapter, we will review those encephalopathies of subacute or chronic onset, which almost always follow an irreversible clinical course and occur during, or more often after, chemotherapy.
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