Titlebook: Neuroimmune Diseases; From Cells to the Li Hiroshi Mitoma,Mario Manto Book 20191st edition Springer Nature Switzerland AG 2019 neuroimmunol

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Significance of Autoantibodiesutoimmunity targeting brain proteins is enigmatic, because traditionally, the central nervous system (CNS) is viewed as immune-privileged. However, the discovery of the lymphatic and glymphatic circulation in the CNS demonstrates the interaction between the CNS and the immune response. Furthermore,

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Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases μm, the brain evolves a barrier at the capillary and postcapillary venules to prevent toxicity during serum fluctuations in metabolites and hormones, to limit brain swelling during inflammation, and to prevent pathogen invasion. Understanding of neuroprotective barriers has since evolved to incorpo

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Structural and Functional Characteristics of the Human Blood-Nerve Barrier with Translational Implic responsible for structural integrity and the inner perineurium consisting of multiple concentric layers of specialized epithelioid myofibroblasts that surround the innermost endoneurium which consists of myelinated and unmyelinated axons embedded in a looser mesh of collagen fibers. Axons are respo

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Autoimmune Astrocytopathyal conditions stable in the CNS, they are recognized as early and highly active players in immune responses in the CNS, and their dysfunction is believed to contribute to neuroimmune disease..Perhaps one of the most important discoveries in recent years has been the identification of IgG-NMO, a spec

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Genetic Factors in Neuroimmune Diseasesor the peripheral nervous system. Unlike monogenic diseases, neuroimmune disorders do not follow Mendelian patterns of inheritance, and their genetic basis has been elusive for decades. It has been only recently that novel methodologies of analysis, such as the genome-wide association study (GWAS) p